Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

Journal article

PURPOSE: Locoregional recurrence is the dominant form of treatment failure in head and neck (HandN) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this disease (

Authors: Gupta, A; Mckenna, W; Weber, C; Feldman, MD; Goldsmith, J

• Publication status: Published
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
• Volume: 8
• Issue: 3
• Pages: 885-892
• Publication date: 2002-03-01
• ISSN: 1078-0432
• Language: English
• Keywords: Oropharyngeal Neoplasms; Radiation Tolerance; Neoplasm Recurrence, Local; Morpholines; Carcinoma, Squamous Cell; Female; Quinazolines; Phosphorylation; Adult; Middle Aged; Prognosis; Blotting, Western; Male; Proto-Oncogene Proteins c-akt; Signal Transduction; Enzyme Inhibitors; Aged; Phosphatidylinositol 3-Kinases; Chromones; Dose-Response Relationship, Radiation; Proto-Oncogene Proteins; Cell Division; Immunoenzyme Techniques; Receptor, Epidermal Growth Factor; Neoplasm Staging; Aged, 80 and over; ras Proteins; Protein-Serine-Threonine Kinases; Humans