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Journal article

Regression mapping of association between the human leukocyte antigen region and Graves disease.

Abstract:

The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown. In the present study, 871 patients with GD and 621 control subjects were genotyped at the DRB1, DQB1, and DQA1 loci. All three loci were associated with GD (P=1.45 x 10(-12), P=3.20 x 10(-5), and P=9.26 x 10(-12), respectively). Stepwise logistic-regression analysis showed ...

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Publisher copy:
10.1086/426947

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Howson, JM More by this author
Heward, JM More by this author
Cordell, HJ More by this author
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Journal:
American journal of human genetics
Volume:
76
Issue:
1
Pages:
157-163
Publication date:
2005-01-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:97fa1200-e622-40be-8a04-bdcec2ad5b34
Source identifiers:
176340
Local pid:
pubs:176340

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