- Abstract:
-
We first examined all the then known alleles (1997) at the HLA-A, B, Bw, C, DRB1, 3, 4 and 5, and DQB1 loci in 55 late-onset (>65y) AD cases and 73 elderly controls from Oxford. We found an association of HLA-B7 with late-onset AD (odds ratio = 3.1, corrected P = 0.04) that was limited to apolipoprotein E epsilon4-negative subjects (odds ratio = 5.1, corrected P = 0.005). We then studied linkages with Class III genes and, finally, we sought to replicate our HLA-B7 result in cohorts from Mo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0197-4580(00)00180-9
-
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- Journal:
- Neurobiology of aging
- Volume:
- 22
- Issue:
- 1
- Pages:
- 71-77
- Publication date:
- 2001-01-01
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- URN:
-
uuid:97f6df4d-f018-40e7-8eac-027364bfa0cd
- Source identifiers:
-
162360
- Local pid:
- pubs:162360
- Copyright date:
- 2001
Journal article
HLA class I, II and III genes in confirmed late-onset Alzheimer's disease.
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