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HLA class I, II and III genes in confirmed late-onset Alzheimer's disease.

Abstract:

We first examined all the then known alleles (1997) at the HLA-A, B, Bw, C, DRB1, 3, 4 and 5, and DQB1 loci in 55 late-onset (>65y) AD cases and 73 elderly controls from Oxford. We found an association of HLA-B7 with late-onset AD (odds ratio = 3.1, corrected P = 0.04) that was limited to apolipoprotein E epsilon4-negative subjects (odds ratio = 5.1, corrected P = 0.005). We then studied linkages with Class III genes and, finally, we sought to replicate our HLA-B7 result in cohorts from Mo...

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Publication status:
Published

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Journal:
Neurobiology of aging
Volume:
22
Issue:
1
Pages:
71-77
Publication date:
2001-01-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:97f6df4d-f018-40e7-8eac-027364bfa0cd
Source identifiers:
162360
Local pid:
pubs:162360

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