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Journal article

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans.

Abstract:

BACKGROUND: Genetic code alterations have been reported in mitochondrial, prokaryotic, and eukaryotic cytoplasmic translation systems, but their evolution and how organisms cope and survive such dramatic genetic events are not understood. RESULTS: Here we used an unusual decoding of leucine CUG codons as serine in the main human fungal pathogen Candida albicans to elucidate the global impact of genetic code alterations on the proteome. We show that C. albicans decodes CUG codons ambiguously a...

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Publication status:
Published

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Publisher copy:
10.1186/gb-2007-8-10-r206

Authors


Miranda, I More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Genome biology
Volume:
8
Issue:
10
Pages:
R206
Publication date:
2007-01-05
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
URN:
uuid:97da3cbc-aee4-49c0-9996-31e39bb20c6f
Source identifiers:
57758
Local pid:
pubs:57758

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