Reproductive history, hormonal factors and the incidence of hip and knee replacement for osteoarthritis in middle-aged women.

Journal article

OBJECTIVES: To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS: A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission records was conducted. The adjusted relative risk (RR) of hip and knee replacement for osteoarthritis was examined in relation to parity, age at menarche, menopausal status, age a...

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Authors: Liu, B; Balkwill, A; Cooper, C; Roddam, A; Brown, A

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 68
• Issue: 7
• Pages: 1165-1170
• Publication date: 2009-07-01
• DOI: 10.1136/ard.2008.095653
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Reproductive History; Humans; Osteoarthritis, Knee; Middle Aged; Female; Prospective Studies; Million Women Study Collaborators; Risk Factors; Arthroplasty, Replacement, Knee; Osteoarthritis, Hip; Menarche; Hormone Replacement Therapy; Menopause; Age Factors; Arthroplasty, Replacement, Hip