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Journal article

An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.

Abstract:

The multidrug resistance P-glycoprotein mediates the extrusion of chemotherapeutic drugs from cancer cells. Characterization of the drug binding and ATPase activities of the protein have made it the paradigm ATP binding cassette (ABC) transporter. P-glycoprotein has been imaged at low resolution by electron cryo-microscopy and extensively analyzed by disulphide cross-linking, but a high resolution structure solved ab initio remains elusive. Homology models of P-glycoprotein were generated usi...

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Publication status:
Published

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Publisher copy:
10.1096/fj.03-0107fje

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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
17
Issue:
15
Pages:
2287-2289
Publication date:
2003-12-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:97c522b7-c62b-445b-b1a2-0e2bdda2f72c
Source identifiers:
100805
Local pid:
pubs:100805

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