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Identification of a novel region of the GABA(B2) C-terminus that regulates surface expression and neuronal targeting of the GABA(B) receptor.

Abstract:

GABA(B) is a G protein-coupled receptor composed of two subunits, GABA(B1) and GABA(B2). GABA(B1) contains an endoplasmic reticulum-retention sequence and is trafficked to the cell surface only in association with GABA(B2). To determine whether the C-terminus of GABA(B2) regulates GABA(B) trafficking, we constructed forms of GABA(B2) with various C-terminal truncations and examined their surface expression. Truncation of GABA(B2) after residue 841 significantly reduced surface expression of b...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The European journal of neuroscience
Volume:
29
Issue:
5
Pages:
869-878
Publication date:
2009-03-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:97bf036d-3653-4879-974b-1f591b537b22
Source identifiers:
55373
Local pid:
pubs:55373

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