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Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV.

Abstract:

Trichogin GA IV (GAIV) is an antimicrobial peptide of the peptaibol family, like the extensively studied alamethicin (Alm). GAIV acts by perturbing membrane permeability. Previous data have shown that pore formation is related to GAIV aggregation and insertion in the hydrophobic core of the membrane. This behavior is similar to that of Alm and in agreement with a barrel-stave mechanism, in which transmembrane oriented peptides aggregate to form a channel. However, while the 19-amino acid long...

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Journal:
Biochimica et biophysica acta
Volume:
1828
Issue:
3
Pages:
1013-1024
Publication date:
2013-03-05
DOI:
EISSN:
1879-2642
ISSN:
0006-3002
URN:
uuid:97b96d4c-fb92-4e50-8261-1db2ea7accfb
Source identifiers:
379496
Local pid:
pubs:379496

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