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Journal article

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer

Abstract:

Treatment personalisation remains an unmet need in oropharynx cancer (OPC). We aimed to determine whether gene expression signatures improved upon clinico-pathological predictors of outcome in OPC. The clinico-pathological predictors, AJCC version 7 (AJCC 7), AJCC 8, and a clinical algorithm, were assessed in 4 public series of OPC (n = 235). Literature review identified 16 mRNA gene expression signatures of radiosensitivity, HPV status, tumour hypoxia, and microsatellite instability. We qual...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-5027-1277
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Role:
Author
ORCID:
0000-0003-2971-7673
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Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
10
Article number:
10226
Publication date:
2020-06-23
Acceptance date:
2020-06-01
DOI:
EISSN:
2045-2322
Pmid:
32576885
Pubs id:
1115533
Local pid:
pubs:1115533
Language:
English
Keywords:
Format:
Electronic

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