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Journal article

Cannabinoids control spasticity and tremor in a multiple sclerosis model.

Abstract:

Chronic relapsing experimental allergic encephalomyelitis (CREAE) is an autoimmune model of multiple sclerosis. Although both these diseases are typified by relapsing-remitting paralytic episodes, after CREAE induction by sensitization to myelin antigens Biozzi ABH mice also develop spasticity and tremor. These symptoms also occur during multiple sclerosis and are difficult to control. This has prompted some patients to find alternative medicines, and to perceive benefit from cannabis use. Al...

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Publication status:
Published

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Publisher copy:
10.1038/35003583

Authors


Croxford, JL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Pertwee, RG More by this author
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Journal:
Nature
Volume:
404
Issue:
6773
Pages:
84-87
Publication date:
2000-03-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:97b7b483-29d2-4217-a63e-420f6da5f3f9
Source identifiers:
368945
Local pid:
pubs:368945

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