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Growth rate, transmission mode and virulence in human pathogens

Abstract:

The harm that pathogens cause to hosts during infection, termed virulence, varies across species from negligible to a high likelihood of rapid death. Classic theory for the evolution of virulence is based on a trade-off between pathogen growth, transmission and host survival, which predicts that higher within-host growth causes increased transmission and higher virulence. However, using data from 61 human pathogens, we found the opposite correlation to the expected positive correlation betwee...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rstb.2016.0094

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Department:
Oxford, MPLS, Zoology
Role:
Author
Natural Environment Research Council More from this funder
AXA Research fund More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Royal Society More from this funder
Royal Commission for the Exhibition of 1851 More from this funder
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Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions of the Royal Society B: Biological Sciences Journal website
Volume:
372
Issue:
1719
Pages:
20160094
Publication date:
2017-03-05
Acceptance date:
2016-09-26
DOI:
ISSN:
0962-8436 and 1471-2970
Pubs id:
pubs:687616
URN:
uri:97ad7ea6-464e-418a-a1fb-84ae0bd37bc3
UUID:
uuid:97ad7ea6-464e-418a-a1fb-84ae0bd37bc3
Local pid:
pubs:687616

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