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Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencyclidine in primates.

Abstract:
The partial glycine agonist d-cycloserine may be of therapeutic use as a cognitive enhancer. We examined the ability of d-cycloserine (3-14 mg/kg i.m.) to reverse cognitive impairments induced by scopolamine (0.03 mg/kg) or PCP (0.25 mg/kg). There was no evidence for a dose-related improvement in visuospatial memory using retention intervals of 2,10 or 20 sec. A possible explanation for these findings is that central glycine function cannot be adequately increased using systemic administration of d-cycloserine in this dose range.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Life sciences
Volume:
50
Issue:
25
Pages:
1959-1962
Publication date:
1992-01-05
DOI:
EISSN:
1879-0631
ISSN:
0024-3205
URN:
uuid:97ab09a4-ace7-4240-9a4c-a547de062681
Source identifiers:
27120
Local pid:
pubs:27120

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