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Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

Abstract:

Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and prolifera...

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Publisher copy:
10.4049/jimmunol.1102719

Authors


Mackay, LK More by this author
van Vliet, CJ More by this author
Mueller, SN More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
188
Issue:
5
Pages:
2173-2178
Publication date:
2012-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:97a853e1-9fb3-4dd1-b675-2bebfd22c0aa
Source identifiers:
491245
Local pid:
pubs:491245

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