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Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

Abstract:

Intercellular adhesion molecule-1 (ICAM-1, CD54) is a ligand for the integrins lymphocyte function associated-1 (LFA-1, CD11a/CD18) and complement receptor-3 (Mac-1, CD11b/CD18) making it an important participant in many immune and inflammatory processes. Modified recombinant soluble ICAM-1 formed dimers. This result indicated that the ectodomain of ICAM-1 contains homophilic interaction sites. Soluble ICAM-1 dimers bind to solid-phase purified LFA-1 with high avidity (dissociation constant [...

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Publisher copy:
10.1084/jem.182.5.1231

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Journal:
The Journal of experimental medicine
Volume:
182
Issue:
5
Pages:
1231-1241
Publication date:
1995-11-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:97a22bb0-0dd6-4b40-bb1a-a4896b14ecf7
Source identifiers:
482684
Local pid:
pubs:482684

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