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Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis.

Abstract:

Many antidepressants are indicated for the treatment of major depression. Two network meta-analyses have provided the most comprehensive assessments to date, accounting for both direct and indirect comparisons; however, these reported conflicting interpretation of results. Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2015-010919

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
BMJ Publishing Group
Journal:
BMJ open More from this journal
Volume:
6
Issue:
7
Pages:
e010919
Publication date:
2016-07-08
Acceptance date:
2016-05-23
DOI:
ISSN:
2044-6055
Pmid:
27401359
Language:
English
Keywords:
Pubs id:
pubs:634105
UUID:
uuid:979f5ed5-eead-4fca-93e1-126dcdfe3cd8
Local pid:
pubs:634105
Source identifiers:
634105
Deposit date:
2016-12-21

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