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In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.

Abstract:

This report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in the immuno-inflammatory response to infection with herpes simplex virus (HSV). Both GITR and GITR-L were transiently upregulated after ocular HSV infection, on antigen-specific T cells and antigen-presenting cells, respectively, in the draining lymph node (DLN). In addition, virus-specific T-cell responses in the DLN and spleen were enhanced by anti-GI...

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Publication status:
Published

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Authors


Sarangi, PP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of virology
Volume:
79
Issue:
18
Pages:
11935-11942
Publication date:
2005-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:979c2695-93bd-4989-be53-e8c4d78eafdd
Source identifiers:
5728
Local pid:
pubs:5728

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