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Journal article

Invasive potential of human rheumatoid tenosynovial cells is in part MT1-MMP dependent.

Abstract:

PURPOSE: In rheumatoid arthritis, tenosynovial invasion of tendon is associated with an increased rate of tendon rupture and a worse clinical prognosis compared to noninvasive disease. Tendon is composed predominantly of type I collagen, which can be efficiently degraded by collagenolytic matrix metalloproteinases (MMPs), one of which, MT1-MMP, is membrane bound and inhibited by tissue inhibitor of metalloproteinase-2, but not by TIMP-1. The role of MT1-MMP in tendon disease is unknown. In th...

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Publication status:
Published

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Publisher copy:
10.1016/j.jhsa.2009.04.015

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Miller, MC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Brennan, F More by this author
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Journal:
The Journal of hand surgery
Volume:
34
Issue:
7
Pages:
1282-1290
Publication date:
2009-09-05
DOI:
EISSN:
1531-6564
ISSN:
0363-5023
URN:
uuid:978e02fc-9571-4549-926c-d7dbedea8d09
Source identifiers:
224381
Local pid:
pubs:224381

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