Mood state moderates the role of serotonin in cognitive biases.

Journal article

Reduction of the monoamine serotonin (5-HT) via the dietary manipulation of tryptophan (acute tryptophan depletion; ATD) has been shown to induce negative cognitive biases similar to those found in depression in healthy individuals. However, evidence also indicates that there can be positive effects of ATD on both mood and reinforcement processing. Here, we present two separate studies, with remarkably similar findings, which may help explain these discrepancies. In both experiments, we asses...

Expand abstract

Authors: Robinson, O; Cools, R; Crockett, M; Sahakian, B

• Publication status: Published
• Journal: Journal of psychopharmacology (Oxford, England)
• Volume: 24
• Issue: 4
• Pages: 573-583
• Publication date: 2010-04-01
• DOI: 10.1177/0269881108100257
• EISSN: 1461-7285
• ISSN: 0269-8811
• Language: English
• Keywords: Cues; Administration, Oral; Double-Blind Method; Humans; Young Adult; Signal Detection, Psychological; Adult; Reward; Serotonin; Beverages; Affect; Reaction Time; Cross-Over Studies; Cognition; Tryptophan; Brain; Female; Male; Mental Recall