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Activation of Ca2+-dependent K+ channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells

Abstract:

We have applied the perforated patch whole-cell technique to 13 cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials. Trains of depolarizations (to simulate glucose-induced electrical activity) resulted in the gradual (time constant: 2.3 s) development of a small (< 0.8 nS) K+ conductance. The current was dependent on Ca2+ influx but unaffected by apamin and charybdotoxin, two blockers of Ca2+-activated K+ channel...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.114.6.759

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Journal:
JOURNAL OF GENERAL PHYSIOLOGY
Volume:
114
Issue:
6
Pages:
759-769
Publication date:
1999-12-05
DOI:
ISSN:
0022-1295
URN:
uuid:978c0e1b-8c9a-4f0d-8903-af3d015464c1
Source identifiers:
15524
Local pid:
pubs:15524

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