- Abstract:
-
We have applied the perforated patch whole-cell technique to 13 cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials. Trains of depolarizations (to simulate glucose-induced electrical activity) resulted in the gradual (time constant: 2.3 s) development of a small (< 0.8 nS) K+ conductance. The current was dependent on Ca2+ influx but unaffected by apamin and charybdotoxin, two blockers of Ca2+-activated K+ channel...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1085/jgp.114.6.759
-
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- Journal:
- JOURNAL OF GENERAL PHYSIOLOGY
- Volume:
- 114
- Issue:
- 6
- Pages:
- 759-769
- Publication date:
- 1999-12-05
- DOI:
- ISSN:
-
0022-1295
- URN:
-
uuid:978c0e1b-8c9a-4f0d-8903-af3d015464c1
- Source identifiers:
-
15524
- Local pid:
- pubs:15524
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
Activation of Ca2+-dependent K+ channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells
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