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Journal article

Mutations in the AXIN1 gene in advanced prostate cancer.

Abstract:

BACKGROUND: The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes ...

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Publication status:
Published

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Authors


Bicknell, DC More by this author
Wilding, JL More by this author
Bartlett, S More by this author
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Journal:
European urology
Volume:
56
Issue:
3
Pages:
486-494
Publication date:
2009-09-05
DOI:
EISSN:
1873-7560
ISSN:
0302-2838
URN:
uuid:97877e94-31c4-4ec9-931a-1e2c72f50c8d
Source identifiers:
177195
Local pid:
pubs:177195

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