Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Burton, PR; Clayton, DG; Cardon, LR; Craddock, N; Deloukas, P; Duncanson, A; Kwiatkowski, DP; McCarthy, MI; Ouwehand, WH; Samani, NJ; Todd, JA; Donnelly, P; Barrett, JC; Davison, D; Easton, D; Evans, DM; Leung, HT; Marchini, JL; Morris, AP; Spencer, CC; Tobin, MD; Attwood, AP; Boorman, JP; Cant, B; Everson, U; Hussey, JM; Jolley, JD; Knight, AS; Koch, K; Meech, E; Nutland, S; Prowse, CV; Stevens, HE; Taylor, NC; Walters, GR; Walker, NM; Watkins, NA; Winzer, T; Jones, RW; McArdle, WL; Ring, SM; Strachan, DP; Pembrey, M; Breen, G; St Clair, D; Caesar, S; Gordon-Smith, K; Jones, L; Fraser, C; Green, EK; Grozeva, D; Hamshere, ML; Holmans, PA; Jones, IR; Kirov, G; Moskivina, V; Nikolov, I; O'Donovan, MC; Owen, MJ; Collier, DA; Elkin, A; Farmer, A; Williamson, R; McGuffin, P; Young, AH; Ferrier, IN; Ball, SG; Balmforth, AJ; Barrett, JH; Bishop, TD; Iles, MM; Maqbool, A; Yuldasheva, N; Hall, AS; Braund, PS; Dixon, RJ; Mangino, M; Stevens, S; Thompson, JR; Bredin, F; Tremelling, M; Parkes, M; Drummond, H; Lees, CW; Nimmo, ER; Satsangi, J; Fisher, SA; Forbes, A; Lewis, CM; Onnie, CM; Prescott, NJ; Sanderson, J; Matthew, CG; Barbour, J; Mohiuddin, MK; Todhunter, CE; Mansfield, JC; Ahmad, T; Cummings, FR; Jewell, DP; Webster, J; Brown, MJ; Lathrop, MG; Connell, J; Dominiczak, A; Marcano, CA; Burke, B; Dobson, R; Gungadoo, J; Lee, KL; Munroe, PB; Newhouse, SJ; Onipinla, A; Wallace, C; Xue, M; Caulfield, M; Farrall, M; Barton, A; Bruce, IN; Donovan, H; Eyre, S; Gilbert, PD; Hilder, SL; Hinks, AM; John, SL; Potter, C; Silman, AJ; Symmons, DP; Thomson, W; Worthington, J; Dunger, DB; Widmer, B; Frayling, TM; Freathy, RM; Lango, H; Perry, JR; Shields, BM; Weedon, MN; Hattersley, AT; Hitman, GA; Walker, M; Elliott, KS; Groves, CJ; Lindgren, CM; Rayner, NW; Timpson, NJ; Zeggini, E; Newport, M; Sirugo, G; Lyons, E; Vannberg, F; Hill, AV; Bradbury, LA; Farrar, C; Pointon, JJ; Wordsworth, P; Brown, MA; Franklyn, JA; Heward, JM; Simmonds, MJ; Gough, SC; Seal, S; Stratton, MR; Rahman, N; Ban, M; Goris, A; Sawcer, SJ; Compston, A; Conway, D; Jallow, M; Newport, M; Sirugo, G; Rockett, KA; Bumpstead, SJ; Chaney, A; Downes, K; Ghori, MJ; Gwilliam, R; Hunt, SE; Inouye, M; Keniry, A; King, E; McGinnis, R; Potter, S; Ravindrarajah, R; Whittaker, P; Widden, C; Withers, D; Cardin, NJ; Davison, D; Ferreira, T; Pereira-Gale, J; Hallgrimsdo'ttir, IB; Howie, BN; Su, Z; Teo, YY; Vukcevic, D; Bentley, D; Brown, MA; Compston, A; Farrall, M; Hall, AS; Hattersley, AT; Hill, AV; Parkes, M; Pembrey, M; Stratton, MR; Mitchell, SL; Newby, PR; Brand, OJ; Carr-Smith, J; Pearce, SH; McGinnis, R; Keniry, A; Deloukas, P; Reveille, JD; Zhou, X; Sims, AM; Dowling, A; Taylor, J; Doan, T; Davis, JC; Savage, L; Ward, MM; Learch, TL; Weisman, MH; Brown, M

Abstract:

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing s...

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APA Style

Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., Ouwehand, W. H., Samani, N. J., Todd, J. A., Donnelly, P., Barrett, J. C., Davison, D., Easton, D., Evans, D. M., Leung, H. T., Marchini, J. L., Morris, A. P., … Brown, M. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39(11), 1329–1337.

MLA Style

Burton, P. R., et al. “Association Scan of 14,500 Nonsynonymous SNPs in Four Diseases Identifies Autoimmunity Variants.” Nature Genetics, vol. 39, no. 11, Nature genetics, 2007, pp. 1329–37.

Chicago Style

Burton, PR, DG Clayton, LR Cardon, N Craddock, P Deloukas, A Duncanson, DP Kwiatkowski, et al. 2007. “Association Scan of 14,500 Nonsynonymous SNPs in Four Diseases Identifies Autoimmunity Variants.” Nature Genetics 39 (11): 1329–37.
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