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The relative phases of basal ganglia activities dynamically shape effective connectivity in Parkinson's disease

Abstract:

Optimal phase alignment between oscillatory neural circuits is hypothesized to optimize information flow and enhance system performance. This theory is known as communication-through-coherence. The basal ganglia motor circuit exhibits exaggerated oscillatory and coherent activity patterns in Parkinson's disease. Such activity patterns are linked to compromised motor system performance as evinced by bradykinesia, rigidity and tremor, suggesting that network fun...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/brain/awv093

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Subgroup:
BNDU
Role:
Author
ORCID:
0000-0002-1641-115X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
ORCID:
0000-0001-8795-5472
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-5201-3044
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
138
Issue:
6
Pages:
1667-1678
Publication date:
2015-04-16
Acceptance date:
2015-02-04
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pubs id:
pubs:518823
URN:
uri:97632f25-dfff-4920-9aa5-8032b46a0eb3
UUID:
uuid:97632f25-dfff-4920-9aa5-8032b46a0eb3
Local pid:
pubs:518823

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