Journal article icon

Journal article

The relative phases of basal ganglia activities dynamically shape effective connectivity in Parkinson's disease

Abstract:

Optimal phase alignment between oscillatory neural circuits is hypothesized to optimize information flow and enhance system performance. This theory is known as communication-through-coherence. The basal ganglia motor circuit exhibits exaggerated oscillatory and coherent activity patterns in Parkinson's disease. Such activity patterns are linked to compromised motor system performance as evinced by bradykinesia, rigidity and tremor, suggesting that network fun...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/brain/awv093

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0002-1641-115X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
ORCID:
0000-0001-8795-5472
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-5201-3044
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
138
Issue:
6
Pages:
1667-1678
Publication date:
2015-04-16
Acceptance date:
2015-02-04
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
25888552
Source identifiers:
518823
Language:
English
Keywords:
Pubs id:
pubs:518823
UUID:
uuid:97632f25-dfff-4920-9aa5-8032b46a0eb3
Local pid:
pubs:518823
Deposit date:
2018-08-24

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP