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Exosomes and the emerging field of exosome-based gene therapy.

Abstract:

Exosomes are a subtype of membrane vesicle released from the endocytic compartment of live cells. They play an important role in endogenous cell-to-cell communication. Previously shown to be capable of traversing biological barriers and to naturally transport functional nucleic acids between cells, they potentially represent a novel and exciting drug delivery vehicle for the field of gene therapy. Existing delivery vehicles are limited by concerns regarding their safety, toxicity and efficacy...

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Publisher copy:
10.2174/156652312802083594

Authors


O'Loughlin, AJ More by this author
Woffindale, CA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Current gene therapy
Volume:
12
Issue:
4
Pages:
262-274
Publication date:
2012-08-05
DOI:
EISSN:
1875-5631
ISSN:
1566-5232
URN:
uuid:9760ab26-6da4-4986-b7f1-a882b0358ef7
Source identifiers:
345657
Local pid:
pubs:345657

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