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Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax.

Abstract:

Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium vivax isolates ex vivo, 10 of which had multiple dhfr mutations associated with Pyr resistance. Despite high-grade resistance to Pyr (median 50% inhibitory concentration [IC₅₀], 13,345 nM), these pa...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiq024

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Russell, B More by this author
Suwanarusk, R More by this author
Leimanis, ML More by this author
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Journal:
The Journal of infectious diseases
Volume:
203
Issue:
2
Pages:
207-210
Publication date:
2011-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:975c462e-c885-4e15-ab93-f9d5ddd12c22
Source identifiers:
115777
Local pid:
pubs:115777

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