Journal article icon

Journal article

Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells.

Abstract:

Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). However, αGalCer leads to overstimulation of iNKT cells. It has been demonstrated that the αGalCer analogue, threitol ceramide (ThrCer 2), successfu...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/jps.22500

Authors


Dawoodji, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Garcia-Diaz, YR More by this author
Expand authors...
Journal:
Journal of pharmaceutical sciences
Volume:
100
Issue:
7
Pages:
2724-2733
Publication date:
2011-07-05
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:975920fc-6f02-47a0-aa14-3f5f4a058c7e
Source identifiers:
135230
Local pid:
pubs:135230

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP