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Journal article

Co-ordination of base excision repair and genome stability.

Abstract:

Base excision repair (BER) is a major DNA repair pathway employed in mammalian cells that is required to maintain genome stability, thus preventing several human diseases, such as ageing, neurodegenerative diseases and cancer. This is achieved through the repair of damaged DNA bases, sites of base loss and single strand breaks of varying complexity that are continuously induced endogenously or via exogenous mutagens. Whilst the enzymes involved in BER are now well known and characterised, the...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
DNA repair
Volume:
12
Issue:
5
Pages:
326-333
Publication date:
2013-05-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:974b6d44-c666-4b08-8df9-ca10b61f4cc0
Source identifiers:
387809
Local pid:
pubs:387809

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