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Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia.

Abstract:

BACKGROUND: Maternal circulating levels of anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1), endoglin (sEng) and placental proteins like activin A and inhibin A are increased before the onset of pre-eclampsia. There is evidence for oxidative stress in pre eclampsia. Recently it was shown that placental oxygen concentration is related to sFlt-1 and inhibin A. In addition it is reported that oxidative stress markers are increased in placental tissue delivered after l...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Redman, CW More by this author
Muttukrishna, S More by this author
Journal:
PloS one
Volume:
4
Issue:
2
Pages:
e4453
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:97402a26-ca85-44a3-be07-790ff682744e
Source identifiers:
248508
Local pid:
pubs:248508

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