- Abstract:
-
Approximately 50% of melanomas require oncogenic B-RAF(V600E) signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although short-term, clinical responses. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets may therefore provide new strategies for managing melanoma. In this report, we applied whole-genome expressio...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/jid.2012.421
-
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- Journal:
- The Journal of investigative dermatology
- Volume:
- 133
- Issue:
- 5
- Pages:
- 1269-1277
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1523-1747
- ISSN:
-
0022-202X
- URN:
-
uuid:973ee6e6-f4ab-4875-9509-d6083dabc68d
- Source identifiers:
-
365496
- Local pid:
- pubs:365496
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.
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