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Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.

Abstract:

Approximately 50% of melanomas require oncogenic B-RAF(V600E) signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although short-term, clinical responses. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets may therefore provide new strategies for managing melanoma. In this report, we applied whole-genome expressio...

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Publication status:
Published

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Publisher copy:
10.1038/jid.2012.421

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Journal:
The Journal of investigative dermatology
Volume:
133
Issue:
5
Pages:
1269-1277
Publication date:
2013-05-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:973ee6e6-f4ab-4875-9509-d6083dabc68d
Source identifiers:
365496
Local pid:
pubs:365496

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