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Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems.

Abstract:

Plasmodium falciparum is unique among the human malarias in displaying the phenomenon of sequestration, in which mature infected erythrocytes adhere to post-capillary and capillary venular endothelium. In this review, Tony Berendt, David Ferguson and Chris Newbold describe the molecular and cellular biology of sequestration and cytoadherence. Potential host receptors identified to date that are expressed on endothelial cells (CD36, thrombospondin and ICAM-1) and the parasite-mediated changes ...

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Publication status:
Published

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Authors


Berendt, AR More by this author
Ferguson, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Parasitology today (Personal ed.)
Volume:
6
Issue:
8
Pages:
247-254
Publication date:
1990-08-05
DOI:
ISSN:
0169-4758
URN:
uuid:972d8acf-37fe-4c07-8452-8ac524839498
Source identifiers:
15796
Local pid:
pubs:15796
Language:
English

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