Journal article
Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients with Non–Small-Cell Lung Cancer: A Randomized Open-Label Phase II Study
- Abstract:
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Chemoresistance is mediated, in part, by the inhibition of apoptosis in tumor cells. Survivin is an antiapoptotic protein that blocks chemotherapy-induced apoptosis. To investigate whether blocking survivin expression enhances docetaxel-induced apoptosis in patients with non–small-cell lung cancer (NSCLC), we compared the antitumor activity of the survivin inhibitor LY2181308 plus docetaxel with docetaxel alone. We used change in tumor size (CTS) as a primary endpoint to assess its use in ear...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 171.3KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 202.1KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 11.6KB, Terms of use)
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- Publisher copy:
- 10.1097/jto.0000000000000285
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Journal of Thoracic Oncology More from this journal
- Issue:
- 11
- Publication date:
- 2014-11-01
- DOI:
- EISSN:
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1556-1380
- ISSN:
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1556-0864
- Pmid:
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25436803
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:491976
- UUID:
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uuid:972bf8ff-94e3-44ca-bcca-5e71ef8bb743
- Local pid:
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pubs:491976
- Source identifiers:
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491976
- Deposit date:
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2018-03-05
Terms of use
- Copyright holder:
- International Association for the Study of Lung Cancer
- Copyright date:
- 2014
- Notes:
- © 2014 International Association for the Study of Lung Cancer. All rights reserved. This is the Accepted Manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1097/jto.0000000000000285
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