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Pyridostigmine enhances, but does not normalise, the GH response to GH-releasing hormone in obese subjects.

Abstract:

Obese patients are characterised by several neuroendocrine abnormalities, including characteristically a decrease in growth hormone responsiveness to GH-releasing hormone. In normal subjects, the GH response to GHRH is enhanced by the acetylcholinesterase inhibitor, pyridostigmine. We have studied the effect of this drug on GH secretion in gross obesity. Twelve obese patients were studied (mean weight 156% of ideal) and compared with a group of 8 normal volunteers. Each subject was initially ...

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Publication status:
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Authors


Castro, RC More by this author
Vieira, JG More by this author
Chacra, AR More by this author
Besser, GM More by this author
Grossman, AB More by this author
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Journal:
Acta endocrinologica
Volume:
122
Issue:
3
Pages:
385-390
Publication date:
1990-03-05
ISSN:
0001-5598
URN:
uuid:96fbe300-241d-459e-85ab-f35f0b7aa1b6
Source identifiers:
138741
Local pid:
pubs:138741

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