Structures of the RNA-guided surveillance complex from a bacterial immune system.

Journal article

Bacteria and archaea acquire resistance to viruses and plasmids by integrating short fragments of foreign DNA into clustered regularly interspaced short palindromic repeats (CRISPRs). These repetitive loci maintain a genetic record of all prior encounters with foreign transgressors. CRISPRs are transcribed and the long primary transcript is processed into a library of short CRISPR-derived RNAs (crRNAs) that contain a unique sequence complementary to a foreign nucleic-acid challenger. In Esche...

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Authors: Wiedenheft, B; Lander, G; Zhou, K; Jore, M; Brouns, S

• Publication status: Published
• Journal: Nature
• Volume: 477
• Issue: 7365
• Pages: 486-489
• Publication date: 2011-09-21
• DOI: 10.1038/nature10402
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Protein Conformation; Escherichia coli K12; Escherichia coli Proteins; Inverted Repeat Sequences; RNA, Bacterial; Models, Biological; Macromolecular Substances; Cryoelectron Microscopy; Base Pairing; Models, Molecular