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Targeting TRIM5 alpha in HIV cure strategies for the CRISPR-Cas9 era

Abstract:

In the past decade, studies of innate immune activity against HIV-1 and other retroviruses have revealed a powerful array of host factors that can attack the virus at various stages of its life cycle in human and primate cells, raising the prospect that these antiviral factors could be manipulated in immunotherapeutic strategies for HIV infection. This has not proved straightforward: while HIV accessory genes encode proteins that subvert or destroy many of these restriction factors, others, s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.01616

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Divisional Administration; MSD Office
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Oxford college:
St Cross College
Role:
Author
Commonwealth Scholarship Commission More from this funder
Research Council of Norway More from this funder
Rosetrees Foundation More from this funder
British HIV Association More from this funder
Centre for AIDS research, University of Kumamoto More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Pages:
1616
Publication date:
2017-11-05
Acceptance date:
2017-11-08
DOI:
EISSN:
1664-3224
Pubs id:
pubs:809699
URN:
uri:96e9b092-5cc2-4193-8abf-6bcea60407dd
UUID:
uuid:96e9b092-5cc2-4193-8abf-6bcea60407dd
Local pid:
pubs:809699

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