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Discovery of unconventional kinetochores in kinetoplastids.

Abstract:

The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of universality. Here, we report the identification of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei. The majority is conserved among kinetopl...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2014.01.049

Authors


Akiyoshi, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Cell
Volume:
156
Issue:
6
Pages:
1247-1258
Publication date:
2014-03-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:96e6cbda-5190-40e6-abfe-a91eae09ab4f
Source identifiers:
451096
Local pid:
pubs:451096

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