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Constraints on GPCR heterodimerization revealed by the type-4 induced-association BRET assay

Abstract:

G-protein-coupled receptors (GPCRs) comprise the largest and most pharmacologically important family of cell-surface receptors encoded by the human genome. In many instances, the distinct signaling behavior of certain GPCRs has been explained in terms of the formation of heteromers with, for example, distinct signaling properties and allosteric cross-regulation. Confirmation of this has, however, been limited by the paucity of reliable methods for probing heteromeric GPCR interactions in situ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bpj.2018.09.034

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR; RDM - Investigative Medicine Division
ORCID:
0000-0001-5531-9244
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Weatherall Insti. of Molecular Medicine
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Grant:
207547/Z/17/Z to S.J.D.
Publisher:
Cell Press Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
116
Issue:
1
Pages:
31-41
Publication date:
2018-11-22
Acceptance date:
2018-09-21
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pubs id:
pubs:955011
URN:
uri:96e5416d-7ff2-4122-8225-ec72d57c7959
UUID:
uuid:96e5416d-7ff2-4122-8225-ec72d57c7959
Local pid:
pubs:955011
Language:
English

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