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Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.

Abstract:

This study describes quantitative investigations of the impact of single charge mutations on equilibrium binding, kinetics, and the adhesion strength of the CD2-CD58 interaction. Previously steered molecular dynamics simulations guided the selection of the charge mutants investigated, which include the CD2 mutants D31A, K41A, K51A, and K91A. This set includes mutations in which the previous cell aggregation and binding data either agreed or disagreed with the steered molecular dynamics predic...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m607968200

Authors


Kearney, A More by this author
Avramovic, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Leckband, DE More by this author
Journal:
The Journal of biological chemistry
Volume:
282
Issue:
8
Pages:
5589-5596
Publication date:
2007-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:96e53df6-0e98-4890-a0d5-87b5aa50c8b3
Source identifiers:
15531
Local pid:
pubs:15531

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