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Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Abstract:

Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a 3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral blood. Meanwhile, droplet-based and plate-based single-cell RNA sequencing of paired T cell receptor alpha and beta chain sequences s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-18513-6

Authors


Penkava, F More by this author
Del Castillo Velasco-Herrera, M More by this author
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Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
2020
Article number:
4767
Publication date:
2020-09-21
Acceptance date:
2020-08-27
DOI:
ISSN:
2041-1723
Pubs id:
1133125
Local pid:
pubs:1133125
Language:
English
Keywords:

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