- Abstract:
-
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a 3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral blood. Meanwhile, droplet-based and plate-based single-cell RNA sequencing of paired T cell receptor alpha and beta chain sequences s...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
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(, 0.0b)
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- Publisher copy:
- 10.1038/s41467-020-18513-6
-
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- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Issue:
- 2020
- Article number:
- 4767
- Publication date:
- 2020-09-21
- Acceptance date:
- 2020-08-27
- DOI:
- ISSN:
-
2041-1723
- Pubs id:
-
1133125
- Local pid:
- pubs:1133125
- Language:
- English
- Keywords:
- Copyright holder:
- Penvaka et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- License:
- CC Attribution (CC BY)
Journal article
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
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