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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.

Abstract:

A panel of anti-gp120 human monoclonal antibodies (HuMAbs), CD4-IgG, and sera from people infected with human immunodeficiency virus type 1 (HIV-1) was tested for neutralization of nine primary HIV-1 isolates, one molecularly cloned primary strain (JR-CSF), and two strains (IIIB and MN) adapted for growth in transformed T-cell lines. All the viruses were grown in mitogen-stimulated peripheral blood mononuclear cells and were tested for their ability to infect these cells in the presence and a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, Jenner Institute
Role:
Author
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Journal:
Journal of virology
Volume:
69
Issue:
1
Pages:
101-109
Publication date:
1995-01-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:96d303ec-1e94-422d-9f24-08e65523ccbc
Source identifiers:
30698
Local pid:
pubs:30698

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