- Abstract:
- Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2962 controls,followed by replication in 1025 PSC cases and 2174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x (10(-16) and P = 4.1 x 10(-8) respectively).
- Publication status:
- Published
- Publisher copy:
- 10.1002/hep.24333
-
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- Journal:
- Hepatology (Baltimore, Md.)
- Volume:
- 53
- Issue:
- 6
- Pages:
- 2133-2135
- Publication date:
- 2011-06-05
- DOI:
- EISSN:
-
1527-3350
- ISSN:
-
0270-9139
- URN:
-
uuid:96ce8d03-4636-4a82-b17b-91cee3f727e9
- Source identifiers:
-
171684
- Local pid:
- pubs:171684
- Language:
- English
- Copyright date:
- 2011
Journal article
Genome-wide association studies in primary sclerosing cholangitis: still more questions than answers?
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