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Genome-wide association studies in primary sclerosing cholangitis: still more questions than answers?

Abstract:
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2962 controls,followed by replication in 1025 PSC cases and 2174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x (10(-16) and P = 4.1 x 10(-8) respectively).
Publication status:
Published

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Publisher copy:
10.1002/hep.24333

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Hepatology (Baltimore, Md.)
Volume:
53
Issue:
6
Pages:
2133-2135
Publication date:
2011-06-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:96ce8d03-4636-4a82-b17b-91cee3f727e9
Source identifiers:
171684
Local pid:
pubs:171684
Language:
English

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