- Abstract:
-
In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20110345
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 208
- Issue:
- 11
- Pages:
- 2305-2320
- Publication date:
- 2011-10-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:96cc94c8-4286-424d-8ee7-e30e828b4c4d
- Source identifiers:
-
193470
- Local pid:
- pubs:193470
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
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