Journal article icon

Journal article

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

Abstract:

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.20110345

Authors


Expand authors...
Journal:
The Journal of experimental medicine
Volume:
208
Issue:
11
Pages:
2305-2320
Publication date:
2011-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:96cc94c8-4286-424d-8ee7-e30e828b4c4d
Source identifiers:
193470
Local pid:
pubs:193470

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP