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“To cross-seed or not to cross-seed”: A pilot study using metallo-β-lactamases

Abstract:

Knowledge of protein structures is of central importance in modern drug discovery and molecular biology, but to be useful the structures, including those obtained in the crystalline state, must be biologically relevant. Small variations in crystallization conditions can lead to alternative crystal forms, conformations, and oligomerization states, causing changes which can lead to altered fold and active site architectures. In the determination of protein structures by X-ray crystallography, c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.cgd.6b01805

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Crystal Growth & Design Journal website
Volume:
17
Issue:
2
Pages:
913-924
Publication date:
2016-12-01
Acceptance date:
2016-12-19
DOI:
EISSN:
1528-7505
ISSN:
1528-7483
Source identifiers:
680405
Keywords:
Pubs id:
pubs:680405
UUID:
uuid:96cadde4-ef30-4cce-801c-a298d2c6661a
Local pid:
pubs:680405
Deposit date:
2017-02-20

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