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“To cross-seed or not to cross-seed”: A pilot study using metallo-β-lactamases

Abstract:

Knowledge of protein structures is of central importance in modern drug discovery and molecular biology, but to be useful the structures, including those obtained in the crystalline state, must be biologically relevant. Small variations in crystallization conditions can lead to alternative crystal forms, conformations, and oligomerization states, causing changes which can lead to altered fold and active site architectures. In the determination of protein structures by X-ray crystallography, c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1021/acs.cgd.6b01805

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Author
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MSD, NDM, Tropical Medicine
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Department:
Oxford, MSD, Pathology Dunn School
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Publisher:
American Chemical Society Publisher's website
Journal:
Crystal Growth & Design Journal website
Volume:
17
Issue:
2
Pages:
913-924
Publication date:
2016-12-05
Acceptance date:
2016-12-19
DOI:
EISSN:
1528-7505
ISSN:
1528-7483
Pubs id:
pubs:680405
URN:
uri:96cadde4-ef30-4cce-801c-a298d2c6661a
UUID:
uuid:96cadde4-ef30-4cce-801c-a298d2c6661a
Local pid:
pubs:680405
Keywords:

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