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Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Abstract:

Sulphonylurea drugs are the therapy of choice for treating neonatal diabetes (ND) caused by mutations in the ATP-sensitive K(+) channel (KATP channel). We investigated the interactions between MgATP, MgADP, and the sulphonylurea gliclazide with KATP channels expressed in Xenopus oocytes. In the absence of MgATP, gliclazide block was similar for wild-type channels and those carrying the Kir6.2 ND mutations R210C, G334D, I296L, and V59M. Gliclazide abolished the stimulatory effect of MgATP on a...

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Publication status:
Published

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Publisher copy:
10.2337/db13-0531

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Diabetes
Volume:
62
Issue:
11
Pages:
3909-3919
Publication date:
2013-11-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:96c839d0-a4f4-4167-8e48-c1d05ef40d04
Source identifiers:
410911
Local pid:
pubs:410911

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