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Journal article

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

Abstract:
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
Publication status:
Published

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Publisher copy:
10.1038/ng.2007.41

Authors


Howarth, K More by this author
Carvajal-Carmona, L More by this author
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Journal:
Nature genetics
Volume:
40
Issue:
1
Pages:
26-28
Publication date:
2008-01-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:96a4c82c-cefb-46d6-9d82-811d7f9a68dc
Source identifiers:
6047
Local pid:
pubs:6047

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