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111In-BnDTPA-F3: An Auger electron-emitting radiotherapeutic agent that targets nucleolin

Abstract:

Introduction: The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membrane of some cancer cells. The goal was to investigate the use of 111In-labeled F3 peptide for Auger electron-targeted radiotherapy. Methods: F3 was labeled with fluorescein isothiocyanate (FITC) for confocal microscopy and conjugated to p-SCNbenzyl- diethylenetriaminepentaa...

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Publisher copy:
10.1186/2191-219X-2-9

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
EJNMMI Research
Volume:
2
Issue:
1
Pages:
1-11
Publication date:
2012-07-23
DOI:
EISSN:
2191-219X
URN:
uuid:969c5e62-48e7-450e-b6f6-b8df44cc5477
Source identifiers:
396163
Local pid:
pubs:396163

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