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Journal article

Disrupted circadian rhythms in a mouse model of schizophrenia.

Abstract:

Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms [2]. However, mechanistic basis for this association remains unknown. Therefore, we investigated the circadian phenotype of blind-drunk (Bdr), a mouse model of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversible by antipsychotic treatment [...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2011.12.051

Authors


Oliver, PL More by this author
Sobczyk, MV More by this author
Maywood, ES More by this author
Edwards, B More by this author
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Journal:
Current biology : CB
Volume:
22
Issue:
4
Pages:
314-319
Publication date:
2012-02-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:968acfdf-a35f-46e8-b067-655977595697
Source identifiers:
241962
Local pid:
pubs:241962

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