Disrupted circadian rhythms in a mouse model of schizophrenia.
Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia  and often precedes related symptoms . However, mechanistic basis for this association remains unknown. Therefore, we investigated the circadian phenotype of blind-drunk (Bdr), a mouse model of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversible by antipsychotic treatment [...Expand abstract
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