Journal article
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
- Abstract:
- We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
- Publication status:
- Published
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- Publisher copy:
- 10.1038/ng.145
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Authors
Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 40
- Issue:
- 6
- Pages:
- 710-712
- Publication date:
- 2008-06-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
135766
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:135766
- UUID:
-
uuid:968ac491-dd17-4e14-ba25-1cfe731a326a
- Local pid:
- pubs:135766
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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