Journal article icon

Journal article

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

Abstract:
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ng.145

Authors


Expand authors...
Journal:
Nature genetics
Volume:
40
Issue:
6
Pages:
710-712
Publication date:
2008-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:968ac491-dd17-4e14-ba25-1cfe731a326a
Source identifiers:
135766
Local pid:
pubs:135766

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP