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Journal article

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.

Abstract:

Matrix metalloproteinase-9 (MMP-9) is implicated in tumor metastasis as well as a variety of inflammatory and pathological processes. Although many substrates for MMP-9, including components of the extracellular matrix, soluble mediators such as chemokines, and cell surface molecules have been identified, we undertook a more comprehensive proteomics-based approach to identify new substrates to further understand how MMP-9 might contribute to tumor metastasis. Previous proteomics approaches to...

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Publication status:
Published

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Publisher copy:
10.1074/mcp.m800095-mcp200

Authors


Suenaga, N More by this author
Edelmann, MJ More by this author
Fridman, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Molecular and cellular proteomics : MCP
Volume:
7
Issue:
11
Pages:
2215-2228
Publication date:
2008-11-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:9687e330-3478-4b5e-842f-78e0b3ec1633
Source identifiers:
21809
Local pid:
pubs:21809

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