Does the addition of a second antipsychotic drug improve clozapine treatment?

Journal article

In patients with schizophrenia who do not have an optimal response to clozapine, it remains unclear if there is an evidence base to support a second antipsychotic in combination with clozapine. The present systematic review was therefore carried out to determine the efficacy of various clozapine combination strategies with antipsychotics. Relevant studies were located by searching the Cochrane Schizophrenia Group Trials Register, Medline, and Embase (up to November 2007). Only studies randoml...

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Authors: Barbui, C; Signoretti, A; Mulè, S; Boso, M; Cipriani, A

• Publication status: Published
• Journal: Schizophrenia bulletin
• Volume: 35
• Issue: 2
• Pages: 458-468
• Publication date: 2009-03-01
• DOI: 10.1093/schbul/sbn030
• EISSN: 1745-1701
• ISSN: 0586-7614
• Language: English
• Keywords: Schizophrenia; Humans; Databases as Topic; Schizophrenic Psychology; Randomized Controlled Trials as Topic; Drug Therapy, Combination; Double-Blind Method; Clozapine; Treatment Outcome; Antipsychotic Agents