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The C-terminus of the metabotropic glutamate receptor 1b regulates dimerization of the receptor.

Abstract:

The Group C G protein-coupled receptors include the metabotropic glutamate receptors (mGluRs), the GABA(B) receptor, the calcium sensor and several taste receptors, most of which are obligate dimers, indeed recent work has shown that dimerization is necessary for the activation of these receptors. Consequently factors that regulate their ability to homo- or heterodimerize are important. The Group 1 mGluRs include mGluR1 and mGluR5 both of which have splice variants with altered C-termini. In ...

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Authors


Remelli, R More by this author
Robbins, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of neurochemistry
Volume:
104
Issue:
4
Pages:
1020-1031
Publication date:
2008-02-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:96842525-6617-46a4-b713-4321b2d00501
Source identifiers:
375610
Local pid:
pubs:375610

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