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Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Abstract:

Introduction: Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of automated and high-throughput screening assays using cell lines. As a result of screening multiple ion-channels there is a need to integrate information, particularly for compounds affecting more than...

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Publisher copy:
10.1016/j.vascn.2013.04.007

Authors


Elkins, RC More by this author
Davies, MR More by this author
Brough, SJ More by this author
Gavaghan, DJ More by this author
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Journal:
Journal of Pharmacological and Toxicological Methods
Volume:
68
Issue:
1
Pages:
112-122
Publication date:
2013-07-05
DOI:
EISSN:
1873-488X
ISSN:
1056-8719
URN:
uuid:96750687-83bc-493c-a91e-c607065a06cf
Source identifiers:
415356
Local pid:
pubs:415356

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